Genomic Signature and Mutation Trend Analysis of Pandemic (H1N1) 2009 Influenza A Virus
Identifieur interne : 000E78 ( Main/Exploration ); précédent : 000E77; suivant : 000E79Genomic Signature and Mutation Trend Analysis of Pandemic (H1N1) 2009 Influenza A Virus
Auteurs : Chungen Pan [États-Unis, République populaire de Chine] ; Byron Cheung [États-Unis] ; Suiyi Tan [États-Unis, République populaire de Chine] ; Chunling Li [République populaire de Chine] ; Lin Li [États-Unis, République populaire de Chine] ; Shuwen Liu [République populaire de Chine] ; Shibo Jiang [États-Unis, République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
A novel swine-origin pandemic influenza A(H1N1) virus (H1N1pdm, also referred to as S-OIV) was identified as the causative agent of the 21st century's first influenza pandemic, but molecular features conferring its ability of human-to-human transmission has not been identified. Here we compared the protein sequences of 2009 H1N1pdm strains with those causing other pandemics and the viruses isolated from humans, swines and avians, and then analyzed the mutation trend of the residues at the signature and non-signature positions, which are species- and non-species-associated, respectively, in the proteins of H1N1pdm during the pandemic of 2009. We confirmed that the host-specific genomic signatures of 2009 H1N1pdm, which are mainly swine-like, were highly identical to those of the 1918 H1N1pdm. During the short period of time when the pandemic alert level was raised from phase 4 to phase 6, one signature residue at the position of NP-100 mutated from valine to isoleucine. Four non-signature residues, at positions NA-91, NA-233, HA-206, and NS1-123, also changed during the epidemic in 2009. All these mutant residues, except that at NA-91, are located in the viral functional domains, suggesting that they may play roles in the human adaption and virulence of 2009 H1N1pdm.
Url:
DOI: 10.1371/journal.pone.0009549
PubMed: 20221396
PubMed Central: 2833199
Affiliations:
- République populaire de Chine, États-Unis
- Guangdong, État de New York
- Jiangmen, Pékin
- Université de Pékin
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B03
- to stream Pmc, to step Curation: 000B03
- to stream Pmc, to step Checkpoint: 000945
- to stream Ncbi, to step Merge: 000501
- to stream Ncbi, to step Curation: 000501
- to stream Ncbi, to step Checkpoint: 000501
- to stream Main, to step Merge: 000E84
- to stream Main, to step Curation: 000E78
Le document en format XML
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Kimball Research Institute, New York Blood Center, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>College of Life Sciences, Peking University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Peking University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Cheung, Byron" sort="Cheung, Byron" uniqKey="Cheung B" first="Byron" last="Cheung">Byron Cheung</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lindsley F. 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Kimball Research Institute, New York Blood Center, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Southern Medical University, Guangzhou, Guangdong, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Southern Medical University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A novel swine-origin pandemic influenza A(H1N1) virus (H1N1pdm, also referred to as S-OIV) was identified as the causative agent of the 21<sup>st</sup> century's first influenza pandemic, but molecular features conferring its ability of human-to-human transmission has not been identified. Here we compared the protein sequences of 2009 H1N1pdm strains with those causing other pandemics and the viruses isolated from humans, swines and avians, and then analyzed the mutation trend of the residues at the signature and non-signature positions, which are species- and non-species-associated, respectively, in the proteins of H1N1pdm during the pandemic of 2009. We confirmed that the host-specific genomic signatures of 2009 H1N1pdm, which are mainly swine-like, were highly identical to those of the 1918 H1N1pdm. During the short period of time when the pandemic alert level was raised from phase 4 to phase 6, one signature residue at the position of NP-100 mutated from valine to isoleucine. Four non-signature residues, at positions NA-91, NA-233, HA-206, and NS1-123, also changed during the epidemic in 2009. All these mutant residues, except that at NA-91, are located in the viral functional domains, suggesting that they may play roles in the human adaption and virulence of 2009 H1N1pdm.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gjd" uniqKey="Smith G">GJD Smith</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name></author><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Watanabe, T" 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Talon</name></author><author><name sortKey="Horvath, Cm" uniqKey="Horvath C">CM Horvath</name></author><author><name sortKey="Polley, R" uniqKey="Polley R">R Polley</name></author><author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name></author><author><name sortKey="Muster, T" uniqKey="Muster T">T Muster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name></author><author><name sortKey="Muster, T" uniqKey="Muster T">T Muster</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, Sh" uniqKey="Seo S">SH Seo</name></author><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, Q" uniqKey="Ye Q">Q Ye</name></author><author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name></author><author><name sortKey="Tao, Yj" uniqKey="Tao Y">YJ Tao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biswas, Sk" uniqKey="Biswas S">SK Biswas</name></author><author><name sortKey="Boutz, Pl" uniqKey="Boutz P">PL Boutz</name></author><author><name sortKey="Nayak, Dp" uniqKey="Nayak D">DP Nayak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, C" uniqKey="Pan C">C Pan</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Liao, M" uniqKey="Liao M">M Liao</name></author><author><name sortKey="Zhang, Gh" uniqKey="Zhang G">GH Zhang</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delano, Wl" uniqKey="Delano W">WL Delano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Guangdong</li><li>État de New York</li></region><settlement><li>Jiangmen</li><li>Pékin</li></settlement><orgName><li>Université de Pékin</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Pan, Chungen" sort="Pan, Chungen" uniqKey="Pan C" first="Chungen" last="Pan">Chungen Pan</name></region><name sortKey="Cheung, Byron" sort="Cheung, Byron" uniqKey="Cheung B" first="Byron" last="Cheung">Byron Cheung</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name><name sortKey="Tan, Suiyi" sort="Tan, Suiyi" uniqKey="Tan S" first="Suiyi" last="Tan">Suiyi Tan</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Pan, Chungen" sort="Pan, Chungen" uniqKey="Pan C" first="Chungen" last="Pan">Chungen Pan</name></noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Chunling" sort="Li, Chunling" uniqKey="Li C" first="Chunling" last="Li">Chunling Li</name><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name><name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name><name sortKey="Tan, Suiyi" sort="Tan, Suiyi" uniqKey="Tan S" first="Suiyi" last="Tan">Suiyi Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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